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Eventi e seminari
02/10/2004
EASL International Bilirubin Workshop 2004, Trieste, Italy
THE MOLECULAR BASIS OF BILIRUBIN NEUROTOXICITY AND ENCEPHALOPATHY
Claudio Tiribelli - J. Donald Ostrow
Course Directors
| Claudio Tiribelli, MD PhD Centro Studi Fegato AREA Science Park and Dept. BBCM, University of Trieste Bldg Q AREA Science Park Basovizza 34012 Trieste, Italy ctliver@csf.units.it |
J. Donald Ostrow, MD GI/Hepatology Division HSB AA - 103F Box 356424 University of Washington Medical Center 1959 NE Pacific Street Seattle, WA 98195, U.S.A jdostrow@medicine.washington.edu |
Meeting report published in Journal of Hepatology
INVITED LECTURES
Bilirubin-Induced Neurologic Dysfunction (BIND) and kernicterus
D.K. Stevenson, Stanford, CA, USA
Bilirubin: physical chemistry, protein-binding and antioxidant properties
J.D. Ostrow, Seattle, WA, USA
How bilirubin enters the cell: addressing the confusion about diffusion
S.D. Zucker, Cincinnati, OH, USA
Role of bilirubin in altering the cytokine network and inducing apoptosis and cell death
D. Brites, Lisbon, Portugal
Redox regulation of cellular functions: New perspectives for the antioxidant role of bilirubin
G.L. Tell, Udine, Italy
Role of glutamate/NMDA receptors and calcium in bilirubin neurotoxicity
S. Shapiro, Richmond, VA, USA
Neuroprotective functions of the blood-CSF and blood-brain barriers: role of transporters and conjugation pathways
J.F. Ghersi-Egea, Lyon, France
ABC transporters and bilirubin
R.P.J. Oude-Elferink, Amsterdam, The Netherlands
Protective role of MRP1
L. Pascolo, Trieste, Italy
Bilirubin Neurotoxicty: Potential Modulation by P-glycoprotein
J. Watchko, Pittsburgh, PA, USA
UCB as a pro-oxidant and potential ligand of the aryl hydrocarbon receptor
J.R. Bend, London, Ontario, Canada
Possible role for glutatione S-transferases in bilirubin binding in the CNS
T.D. Boyer, Tucson, AZ, USA
POSTER SESSION
Relevance of oxidative stress in the pathways of neuronal damage by unconjugated bilirubin.
MA Brito, A Fernandes, AS Falcăo, RFM Silva, DA Butterfield, D Brites. Centro de Patogénese Molecular (UBMBE), Faculdade de Farmácia, University of Lisbon, Lisbon, Portugal; b Department of Chemistry, Center of Membrane Sciences and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.Hypoxia-ischemia intensifies bilirubin-induced cell death and TNF-a release in cultured astrocytes.
AS Falcao, A Fernandes, MA Brito, RFM Silva, D Brites. Centro de Patogenese Molecular (UBMBE), Faculdade de Farmacia, University of Lisbon, Lisbon, Portugal.Astroglial response to bilirubin involves activation of the TNF-a and NF-?B pathways.
A Fernandes, AS Falcao, C Gordo, MJ Gama, RFM Silva, MA Brito, D Brites.Centro de Patogenese Molecular (UBMBE), Faculdade de Farmacia, University of Lisbon, Lisbon, Portugal.Unconjugated bilirubin enhances the release of pro-inflammatory cytokines and glutamate by rat microglia.
C Gordo, A Fernandes, S Falcăo, A Brito, RFM Silva, D Brites. Centro de Patogénese Molecular (UBMBE), Faculdade de Farmácia, University of Lisbon, Lisbon, Portugal.Orlistat treatment decreases plasma bilirubin concentration in gunn rats by increasing turnover of bilirubin.
Anja M. Hafkamp, Rick Havinga, Lorella Pascolo, and Henkjan J. Verkade. Department of Pediatrics, University Hospital Groningen, Groningen, The Netherlands; CSF and Department of BiochemistAry, Biophysics and the Chemistry of Macromolecules, University of Trieste, Trieste, Italy.Neonatal bilirubin production-conjugation imbalance: effect of glucose-6-phosphate dehydrogenase deficiency and borderline prematurity.
Michael Kaplan, MB ChB, Maurizio Muraca, MD, Hendrik J Vreman, PhD, Cathy Hammerman, MD, Maria Teresa Vilei, MD, Firmino F Rubaltelli, MD, David K Stevenson, MD. Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Faculty of Medicine of the Hebrew University, Jerusalem, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva, Israel; Department of Internal Medicine, University of Padua, Padua, Department of Neonatology, University of Florence, Florence, Italy; Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University Medical Center, Stanford, CA.Current use of phototherapy (PTX) and monitoring of total serum bilirubin in extremely low birth weight (ELBW) infants.
B Morris, G McDavid, W Oh, D Stevenson, J Tyson, D Phelps, O’Shea, R Higgins, K Poole, C. Grisby on behalf of the NICHD Neonatal Research Network, USA.Unconjugated bilirubin modulates the intestinal epithelial barrier function in a human-derived, in vitro model.
Francesco Raimondi, Valeria Crivaro, Maria Vendemmia, Luigi Maiuri, Pasquale Santoro, Maria Tucci, Roberto Paludetto. Division of Neonatology, Department of Pediatrics, Universitŕ "Federico II", Naples, Italy.Unconjugated bilirubin affects fecal protein loss and clinical presentation of food allergy in healthy term neonates. A pilot, clinical study.
Francesco Raimondi, Gabriella Araimo, Giuseppe Di Bernardo, Valeria Crivarao, Letizia Capasso, Roberto Berni Canani, Annalisa Passariello, Gianluca Terrin, Roberto Paludetto. Division of Neonatology and Pediatric Gastroenterology, Dept of Pediatrics, Universitŕ "Federico II" di Napoli, Naples, Italy.Direct evidence of bilirubin uptake into liver cells by Bilitranslocase.
M.Terdoslavich, A.Cocolo, N.Medic, A.Margon, M.Franko, G.Decorti and S.Passamonti. Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universitŕ di Trieste, Italy; Laboratory for Environmental Research, Nova Gorica Polytechnic, Slovenia, Dipartimento di Scienze Biomediche, Universitŕ di Trieste, Italy.Oral administration of zinc salts efficiently decreases serum bilirubin levels in hyperbilirubinemic rats.
Libor Vítek, Lucie Muchová, Jaroslav Zelenka, Marie Zadinová, Ji r í Malina. Institute of Clinical Biochemistry and Laboratory Diagnostics and 4th Department of Internal Medicine, Institute of Medical Biophysics, 1st Medical Faculty, Charles University of Prague, Department of Clinical Microbiology, Barrandov Outpatient Center, Prague, Czech Republic.Lipid peroxidation-generated carbon monoxide in mice: effect of vitamin e and metalloporphyrins.
Hendrik J. Vreman, Ronald J. Wong, Ganesh Shankar, David K. Stevenson. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.In vitro efficacy measurements of led-based phototherapy devices compared to traditional light sources in a model system.
Hendrik J. Vreman, Ronald J. Wong, Jamie R. Murdock, David K. Stevenson. Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, Natus Medical, San Carlos, CA, USA.Bilirubin co-transports protons across membranes.
Richard Wennberg, David Zakim, David Deamer. Dept. of Pediatrics, U. of Washington1, Dept. of Medicine, Cornell University2, Dept. of Zoology, U. California, Davis3, USA.Effects of bilirubin on glutamate uptake by synaptomes, NMDA receptor binding in synaptic membranes, and glutamate receptors expressed in oocytes.
Richard Wennberg, Essam Enan, Uhllrich Musshoff. Dept. of Pediatrics, U. of Washington1, Dept. of Environmental Toxicology, U. of California, Davis2, Dept. of Physiology, U. Muenster3, USA.Developmental Regulation of Heme Oxygenase Expression in the Mouse Brain.
Ronald J. Wong, Hui Zhao, Aida Abate, Hendrik J. Vreman, Christopher H. Contag, David K. Stevenson. Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA