As for the Gilbert syndrome, the circulating bilirubin levels, slightly above the normal values, can be a protective factor against the onset of other diseases, such as Parkinson's disease
NUMBERS
At diagnosis, the 30-40% of dopaminergic neurons have been already lost
There is no effective treatment available
UNMET CLINICAL NEEDS
- To identify the early molecular mechanisms responsible for the neurons loss .
- to identify new therapies able to slower the progression or avoid the onset of the disease. Including the repositionig of currently used drugs.
- To improve the diagnosis.
We aim to identify the early mechanisms responsible for the loss of the dopaminergic neurons (DOPAN), causing the motor disfunctions, and to investigate the potential protective role of bilirubin and other natural compounds against DOPAN loss. Moreover, we actively evaluate the efficacy and safety of nanovectors for delivering such compounds into the brain cells.
IL NOSTRO OBIETTIVO
Prevention and slowing of the progression of the disease
HOW
Ideas
Collaboration
Effort
Studying the protective role of bilirubine and natular compounds delivered by nanovectors
Multidisciplinary, with the joint collaboration of engineers, physicists, doctors, pharmacologists and biologists
In sharing knowledge and expertieses