Name of the Group:
Liver Cancer Unit
Board Members:
Devis Pascut (Senior Scientist)
Luca Grisetti (Postdoc Researcher)
Francesco Cattani (Postdoc Researcher)
Benedetta Blarasin (Postdoc Researcher)
Elisabetta Sorrentino (Master Student)
Ludovica Varnier (Master Student)
Caecilia Sukowati (Senior Scientist)
Cyrollah Disoma (PhD Student)
Georgia Zancotti (PhD Student)
Research Description:
The research group focuses on translational research in the field of liver cancers, with particular interest on circulating biomarkers, identification of molecular targets for therapies, immunotherapies, drug resistance, cancer cells heterogeneity, and cancer stem cells. The group actively engages in collaborative partnerships with SMEs, large companies, hospitals and research institutions in Europe, Asia, and America, to facilitate the development of research projects and tools that promote the translation of scientific findings from the laboratory to clinical practice and vice versa. By fostering these collaborations, the group aims to enhance the transferability of research outcomes, ultimately benefiting patients and healthcare practices.
In detail, the group is currently studying:
- Adaptive mechanisms leading to multidrug resistance in HCC
• Telomerase regulation in HCC
• Inhibition of hepatocarcinogenesis by using a newly synthesized molecule against HA38
• Cellular heterogeneity of Eastern vs western: distribution of stem cells markers in HCC cases
from European vs Asian regions
• Ferroptosis and hepatocellular carcinoma: Its relevance in drug resistance
• Regorafenib and PRG4 to target hepatocellular carcinoma
• Development of an eHealth data analysis platform for obesity associated liver disease through
the integration clinic-biochemical and omics information
• Unrevealing the role of miR-3185 in HCC
• AukA inhibitors as combinatorial therapy with immune checkpoint inhibitors in HCC
• The role of DLG5 in HCC
• Analysis of miRNA profiles in HCC patients
• Targeting immune checkpoints of heterogeneous cellular populations in HCC
• Transcriptomic and Epigenomic Studies on Transplanted Liver
