Team

Liver Cancer Unit

Logo HCC GROUP

Name of the Group:

Liver Cancer Unit

Board Members:
Devis Pascut (Senior Researcher)
Luca Grisetti (PhD Student)
Vivien Josol
(PhD Student)
Clarissa Garcia (PhD Student)
Therriz Mamerto (PhD Student)

Caecilia Sukowati (Senior Researcher)
Cyrollah Disoma (PhD Student)
Georgia Zancotti (Master Degree Student)

Research Description:  

The research group focuses on translational research in the field of liver cancers, with particular interest on circulating biomarkers, identification of molecular targets for therapies, immunotherapies, drug resistance, cancer cells heterogeneity, and cancer stem cells. The group actively engages in collaborative partnerships with SMEs, large companies, hospitals and research institutions in Europe, Asia, and America, to facilitate the development of research projects and tools that promote the translation of scientific findings from the laboratory to clinical practice and vice versa. By fostering these collaborations, the group aims to enhance the transferability of research outcomes, ultimately benefiting patients and healthcare practices. 

In dettaglio, il gruppo sta attualmente studiando:
1) Il ruolo dell’Aurora chinasi A nel cancro del fegato ei benefici derivati da un trattamento sinergico che include inibitori AURKA e inibitori del checkpoint immunitario;
2) I ruoli extra-telomerici della telomerasi e il suo valore come biomarcatore prognostico dopo resezione epatica;
3) Biopsia liquida per la diagnosi precoce del cancro;
4) Il valore dei trasportatori di zinco come possibili bersagli per la terapia antitumorale;
5) Valutazione e identificazione di potenziali nuove terapie molecolari mirate del carcinoma epatocellulare;
6) Patogenesi molecolare dell’HCC correlato ad epatite virale; e
7) Sviluppo di un nuovo vettore di consegna mirato, comprese le nanoparticelle.